Apoptosis, Senescence and Cancer by David A. Gewirtz, Shawn E. Holt, Steven Grant

By David A. Gewirtz, Shawn E. Holt, Steven Grant

This booklet offers perception into tested practices and learn into apoptosis and senescence. the amount completely examines novel and rising strategies and study within the fields of phone loss of life pathways, senescence development arrest, medications and resistance, DNA harm reaction, and different subject matters that also carry mysteries for researchers. In overall, this quantity offers uncomplicated scientists and clinicians with a deeper and extra whole realizing of the mobile responses of malignancies that could make sure the effectiveness of remedy, either within the preliminary phases of the sickness in addition to in ailment recurrence.

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EMBO J 1995; 14(24):6148–56. 41. Frasch SC, Henson PM, Kailey JM, et al. Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta. J Biol Chem 2000; 275:23065–73. 42. Martin SJ, Reutelingsperger CP, McGahon AJ, et al. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J Exp Med 1995; 182(5):1545–56. 43. Hanayama R, Tanaka M, Miwa K, Shinohara A, Iwamatsu A, Nagata S.

J Biol Chem 2003; 278:31469–72. 196. Jones JM, Datta P, Srinivasula SM, et al. Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice. Nature 2003; 425:721–7. 197. Martins LM, Morrison A, Klupsch K, et al. Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice. Mol Cell Biol 2004; 24(22):9848–62. 198. Hegde R, Srinivasula SM, Datta P, et al. The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein.

20. Brown JM, Attardi LD. The role of apoptosis in cancer development and treatment response. Nat Rev Cancer 2005; 5:231–7. 21. Patel T, Gores GJ, Kaufmann SH. The role of proteases during apoptosis. FASEB J 1996; 10(5): 587–97. 22. Jaattela M, Tschopp J. Caspase-independent cell death in T lymphocytes. Nat Immunol 2003; 4(5):416–23. 23. Creagh EM, Martin SJ. Caspases: cellular demolition experts. Biochem Soc Trans 2001; 29:696–702. 24. Boatright KM, Renatus M, Scott FL, et al. A unified model for apical caspase activation.

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