Advances in Immunology, Vol. 46 by Frank J. (Editor) Dixon

By Frank J. (Editor) Dixon

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Physical differences among loci, such as the mouse T cell receptor a-chain and a-chain gene families, as well as differences among analogous loci in different species, such as mice and humans, reveal the development of similar mechanisms with a singular final objective of creating molecular diversity. In all of the immunoglobulin-likeloci, a set of discontinuous gene segments is selected from two to three pools containing from 1 to 100 members; these segments are then joined by DNA rearrangement to produce the final coding sequence.

In the mouse, V, and VH gene subfamilies are thought to be organized in clusters along the chromosomes (see above). , 1988). Kodaira et al. (1986) isolated 23 cosmid clones containing 61 VH gene segments which span approximately 1000 kb of genomic DNA. VH gene segments of different subgroups were found to be present in the same clone. Detailed restriction enzyme analysis of these cosmid clones revealed that VH subgroups are highly interspersed. , 1986). Berman et al. (1988) confirmed these results and showed that VHIV gene segments also are interspersed with the other subgroups.

The Vp and Cp gene elements are indicated by solid boxes; the D and J gene segment clusters are indicated by lines. 3* is a pseudogene. The region of the 0-chain locus that is deleted in SJL mice is indicated by ASJL. , 1987). A Vp gene segment isolated by Singer et al. (1986)has been renamed as Val7 in agreement with the existing nomenclature. , 1988). The mouse @chain family is unique among the immunoglobulin-like loci in that most of the subfamilies contain only a single member. , 1987; Lee and Davis, 1988).

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