Advances in Drug Research, Vol. 26 by Bernard Testa, Urs A. Meyer (Eds.)

By Bernard Testa, Urs A. Meyer (Eds.)

Quantity 26 keeps the craze of shorter, extra widespread volumes. With quantity 25, the sequence received a brand new co-editor, Urs Meyer. whereas conserving the dedication to put up chapters on healing or chemical sessions and on basic subject matters or options, the sequence' insurance has increased to incorporate methodological chapters, and new parts of well-known or power value to drug examine, specifically in molecular pharmacology.

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TESTA B ) FIG. 9. Schematic translational interpretation of Fig. 8. As a result of their mutual interactions, a drug D and a biological system B exist in a number of states as explained in the text (Testa, 1987). studies involving enzyme induction (or inhibition) where a drug is used both as an inducer (or inhibitor) and then as a substrate. Note that Fig. 9 only describes situations involving a single drug; the simultaneous or sequential involvement of two or more agents must lead to transactional situations of greater complexity.

Pharmacol. Ther. 66(Suppl. II), 1-26. Ito, K. and Gunji, Y. P. (1994). Biosvstems 33, 17-24. Kalow, W. and Bertilsson, L. (1994). In "Advances in Drug Research", Vol. 25 (B. Testa and U. A. Meyer, eds), pp. 1-53. Academic Press, London. Kier, L. B. (1967). Mol. Pharmacol. 3,487-493. Kier, L. B. (1970). In "Fundamental Concepts in Drug Receptor Interaction" (J. F. Moran and D. J. ), pp. 15-45. Academic Press, New York. Kier, L. B. (1971). " Academic Press, New York. Kier, L. B. and Cheng, C. K. (1994).

1986). In "Water and Aqueous Solutions" (G. W. Neilsen and J. E. Enderley, eds), pp. 227-244. Adam Hilger Press, Bristol. Frauenfelder, H. (1988). In "From Chemical to Biological Organization" (M. Marcus, S. C. MOiler and G. Nicolis, eds), pp. 177-181. Springer, Berlin. Frauenfelder, H. and Wolynes, P. G. (1994). Physics Today (February), 58-64. , Carrupt, P. , Testa, B. and Boudon, A. (1994). J. -Aided Mol. Design 8, 83-96. Georgopoulos, C. (1992). Trends Biochem. Sci. 17, 295-299. B. KIER AND B.

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