By Peter Scanlon, Stephen Aldington, Charles Wilkinson, David Matthews
This sensible medical handbook covers the analysis, therapy - either clinical and surgical - and long term administration of eye difficulties in individuals with diabetes. aimed toward the MDT serious about the care of sufferers with diabetes, it emphasizes the significance of standard screening and early analysis and offers evidence-based tips.
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Extra info for A Practical Manual of Diabetic Retinopathy Management
Klein R, Klein BE, Moss SE, Davis MD, DeMets DL. The Wisconsin Epidemiologic Study of Diabetic Retinopathy. VII. Diabetic nonproliferative retinal lesions. Ophthalmology 1987; 94(11): 1389–400. Klein R, Klein BE, Moss SE, Davis MD, DeMets DL. The Wisconsin Epidemiologic Study of Diabetic Retinopathy. IX. Four-year incidence and progression of diabetic retinopathy when age at diagnosis is less than 30 years. Arch Ophthalmol 1989; 107(2): 237–43. Klein R, Klein BE, Moss SE, Davis MD, DeMets DL. The Wisconsin Epidemiologic Study of Diabetic Retinopathy.
The commonest type (MODY-3) is caused by hepatic nuclear factor (HNF-1α) abnormalities, and responds well to low-dose sulphonylureas. MODY-2 (about 20% of all MODY) is important to diagnose because it is a wellregulated hyperglycaemic state with a norm set at about 6 mmol/L rather than 4 mmol/L fasting. Because sustained hyperglycaemia is not a feature, those with MODY-2 rarely have macrovascular complications or significant retinopathy. Recent discoveries3,4 of ABCC8 (SUR1) and INS (insulin) gene mutations presenting in patients clinically defined as having MODY will have implications for clinical management.
Stabilization occurred over the next few weeks. Two years later she was requiring 1 unit/kg of body weight per day, and a small increase was required during puberty. 1 Differences between type 1 and type 2 diabetes. Type 1 diabetes Type 2 diabetes Older and alternative names Juvenile-onset diabetes Insulin-dependent diabetes mellitus (IDDM) Maturity-onset diabetes Non-insulin-dependent diabetes mellitus (NIDDM) Onset Any time in life, but teenagers and children are most likely to have this type Generally diagnosed over the age of 40, but can occur in the overweight or in some genetic conditions in younger people Symptoms at onset Thirst, tiredness, weight loss, polyuria, ketoacidosis in extremis Tiredness, nocturia, thrush and skin infections Body type Generally normal-weight or thin Generally overweight Speed of onset Usually becomes critical and needs urgent attention within a few weeks (or even days) of the first symptoms May not be noticed as a problem.